I never would have predicted it -- that a tooth could become a tool for dispensing medication. But the refinement of such a creation is actually in the works and before long, you may be asking not for a gold or decorative tooth but for one capable of doling out your drugs in the exact doses and at the right times.

Think about this:

Researchers from Europe and Israel are working right now on a tiny dispensing system called IntelliDrug. Their goal is to create parts small enough they can fit into a false tooth placed in the back of the mouth. The device will release a specific amount of medication at certain intervals so patients receive the proper dosage right on schedule.

This invention, crafted by an Israeli dentist, could pick up the slack for people who forget to take medicine and could save lives for those whose lives depend on scheduled drug therapy. It could also allow for better absorption of medication into the body.

The IntelliDrug device will deliver medicine directly into the bloodstream through the lining of the cheek around the mouth. Saliva, meanwhile, mixes with the drug and carries it throughout they body in a manner more efficient than just swallowing a pill every few hours.

While researchers hope to one day turn their device into a replacement tooth, the apparatus -- consisting of a stainless steel housing, a pump, custom valves, a microprocessor, batteries, and a reservoir for the drug pill -- currently comes in the form of a block the size of two teeth. It is strapped to the the side of teeth and hugs the inside of the cheek. The unit can be removed, and a technician can refill the drug reservoir, clean the unit, and change batteries when necessary.

Clinical trials on pigs are ongoing. Human testing is expected to begin by the end of the year.

When Dr. Jian-Wei Gu went to Mississippi to study the cardiovascular system and the process of blood vessel growth, he had no idea he'd make national headlines about his research into the world of cancer.

Gu, assistant professor of physiology and biophysics at the University of Mississippi Medical Center, says his discovery of the mechanism by which alcohol consumption causes tumor growth was purely accidental.

And extremely significant.

Scientists have known for a hundred years about the link between alcohol consumption and cancer. A study from Paris in 1910 showed that 80 percent of patients with cancer of the esophagus or gastric track were alcoholics. More recently, scientists have found correlations between alcohol consumption and cancer of the mouth, pharynx, larynx, esophagus, liver, large bowel, and even the breasts. Yet lab experiments have always failed to show the effects in animals that investigators knew to be true in humans.

Until now.

It seems past studies used too much alcohol -- in concentrations of 20 percent -- and the animals just wasted away while showing no tumor growth. But when Gu used concentrations of one percent -- about one to two drinks per day in humans -- to study blood vessel growth, he detected stimulated tumor growth in both chick embryos and mice. Thus, his cancer discovery was born.

Gu has further concluded that melanoma cancers in mice grew significantly faster and larger in the mice who consumed the equivalent of one or two alcoholic drinks a day than the mice receiving no alcohol.

Gu's findings, now confirmed by other scientists, are evidence of what many have long suspected -- alcohol, even in moderation, increases cancer risk.

University of North Carolina football coach Butch Davis recently received a shocking cancer diagnosis after a routine dental visit turned up a suspicious growth in his mouth. Pathology reports identify the cancer as non-Hodgkin's lymphoma.

Davis, 55, has had the growth removed from his gum and while he received his first chemotherapy treatment last week, he's been told there is no indication the cancer has spread to other parts of his body.

Chemotherapy for Davis began at the Cleveland Clinic in Ohio -- Davis coached the National Football League's Cleveland Browns from 2001-2004 -- but will continue at the University of North Carolina Hospital in Chapel Hill.

Davis says he is doing well, that his general health has never been better. And while fighting off cancer, he will work hard at preparing for the 2007 season.

"My family, my health and coaching this football team are my top priorities,'' Davis said. "I would appreciate and expect the focus to remain on the North Carolina football team."

The team opens the season on September 1 against James Madison University.

Increased intake of vitamin C from the diet, but not from supplements may slash the risk of mouth cancer by 48 percent, says an epidemiological study.

The study, published in the International Journal of Cancer, used data on supplement use and diet for 42,340 men in the Health Professional Follow-Up Study. During the course of the study, 207 oral pre-malignant lesions were documented.

Vitamin C from dietary sources was significantly associated with a reduced risk of mouth cancer, but no association with the vitamin from supplements was found.

Vitamin C is needed to form collagen, a tissue that helps to hold cells together. It's essential for healthy bones, teeth, gums, and blood vessels. It helps the body absorb iron and calcium, aids in wound healing and contributes to brain function.

You can find high levels of vitamin C in red berries, kiwi, red and green bell peppers, tomatoes, broccoli, spinach, and juices made from guava, grapefruit and orange.

I just heard someone say that time doesn't heal all wounds -- it just makes them worse. I guess it depends on the wound. I imagine losing a child is one wound that never really heals. But I've found that my cancer wounds -- both physical and emotional -- have healed with time. And a trip down memory lane proves it.

Two years ago I wrote about my wounds, fresh and raw and painful, on my Breast Cancer blog.

Confession
Wednesday, February 23rd, 2005

Dry mouth (xerostomia), is most commonly caused by radiation therapy directed at the head and neck region of the body. Radiation may irreversibly affect the production and quality of saliva in the salivary glands. A number of medications can also induce xerostomia. Dry mouth may affect the patients speech, taste sensation and ability to swallow.

Many patients complain of a sore or burning sensation, cracked lips, and fissures in the corners of the mouth. There is also an increased risk of cavities and mouth disease due to less saliva to cleanse the teeth and gums.

There are now some means of preventing xerostomia that were not available a few years ago. Amifostine, a radiation protector of normal tissues, has been shown to protect the salivary glands when given daily with radiation therapy. Also, a treatment known as Proton therapy may allow the radiation oncologist to spare the salivary glands from getting significant radiation doses. This may prevent dry mouth in the future. If you are getting radiation therapy to the head and neck region, you should discuss these options with your radiation oncologist. If you have developed xerostomia, there are management strategies that can effectively deal with your dry mouth and prevent cavities and periodontal disease.

Try to follow these simple guidelines:

• Perform oral hygiene at least four times a day. (After each meal and before bedtime)
• The oral cavity should be rinsed and wiped immediately after meals
• Dentures need to be brushed and rinsed after meals
• Only use toothpaste with fluoride when brushing
• Keep water handy to keep the mouth moist at all times
• Apply prescription strength fluoride gel at bedtime
• Rinse with salt and baking soda solution 4-6 times a day
• Avoid liquids and foods with high sugar content
• Avoid rinses containing alcohol
• Use moisturizer regularly on lips
• Oral pilocarpine (Salagen) is the only drug approved by the FDA to stimulate saliva secretion from the remaining salivary glands.

The state of New Jersey outpaces the nation in survival of ovarian cancer -- but it lags behind when it comes to surviving endometrial, cervical, skin, mouth, and brain cancers.

New Jerseyans are still surviving cancer. But a report issued Tuesday reveals the state survival rate -- for some reason -- trails the national rate.

The difference between the state and national rates is not large -- about three percentage points separate the two -- but the racial disparity appears more significant. Survival rates for white men and women are about 10 percentage points higher than those for black men and women. This is similar to the national racial gap.

It's likely racial differences are due to later detection, later diagnosis, and less access to treatment and support services.

New Jersey survival rates also vary greatly by type of cancer, sex, and age.

Chemotherapy can upset the digestive system. It can cause nausea and vomiting -- although I never did throw up during my own chemotherapy, thanks to medication for these side effects. Chemotherapy can diminish overall feelings of wellness and can cause sore gums and mouth sores and dry mouths. Clearly, chemotherapy can ruin an appetite.

But patients receiving chemotherapy need to eat. And they need to drink. They need to maintain nutrition and energy and strength during a physically taxing time. And so the challenge facing many entrenched in chemotherapy is how to eat when the act of chewing, swallowing, and digesting food is so completely unappetizing.

Barbara Curtis shares in a chapter of Chicken Soup for the Breast Cancer Survivor's Soul a recipe that made a difference for her sister during her worst days of chemotherapy.

Her recipe -- for chemo popsicles -- includes essential ingredients. Fruit and tofu provide phytochemicals, protein, and liquids for depleted bodies. The cool popsicle soothes sore mouths and settles stomachs. And the ease of putting together this simple snack is nothing short of tempting.

My advice -- save this recipe. And savor it too.

Chemo Popsicles

Fresh-squeezed orange juice, one 8-ounce glass
Frozen mangoes, 1/4 package, or 1 cup frozen berries
1/4 square tofu, medium firmness
One banana
Add passionfruit juice or other fruit juices for flavor

Put all ingredients into a blender. Blend to liquify. Add more juice if mixture is too thick -- it should be as thick as a smoothie. Pour blended mixture into Tupperware or plastic popsicle molds and freeze.

I have a new friend who is a new breast cancer survivor. She is surviving a new diagnosis, a recent lumpectomy, and the moments leading up to another surgery to further investigate the margins surrounding the tumor removed from her breast. She is surviving the first phase of her breast cancer journey. A phase full of uncertainty and fear and panic. A phase so new and so fresh and so raw, her mind is whirling. A phase that has her grasping for any bit of direction she can find as she navigates a terrifying, unfamiliar road.

My friend is a young wife and mother whose worries are consuming her. She e-mailed me today and asked if I ever have moments when I look at my young children and worry that cancer will take me from them while they are young. She asked if I have always been so sure I will be okay. And so I replied with this candid cancer confession.

The Lung Cancer Alliance -- the only national non-profit organization dedicated entirely to lung cancer patient support and advocacy -- asked pulmonary clinical nurse specialist Donna Wilson to help educate the lung cancer community about healthy breathing. Wilson agreed and her breathing tips, available on podcast, are intended to relieve shortness of breath related to pain or activity. Her three breathing techniques -- detailed here -- are simple, easy-to-understand, and truly relaxing.

Before beginning this series of breathing exercises, stop whatever you are doing and sit down or lean against a wall.

• Place chin to your chest to relax your neck muscles. Breathe 10 short bursts of air in and out of your lips. As you expel air, neck and chest muscles should relax.
• Place chin to your chest. Breathe three times in through your nose and out through your mouth.
• Place chin to your chest. Close your mouth, and breathe four times in and out only through your nose.
  

After completing these exercises, lift your head, breathe normally, and let your shoulders relax. In a few minutes, your entire body should start to relax -- and shortness of breath will resolve.

I don't have lung cancer -- but I do have moments of anxiety and panic. So I plan to save these tips. And I plan to use them. And I plan to share them. Because we all can benefit from a dose of relaxation.

Her diagnosis came at the same time as mine -- in November 2004, just after her husband, John Edwards, and John Kerry lost the presidential election. She received the same treatment as I did -- lumpectomy, chemotherapy, and radiation -- and so I was especially interested in her breast cancer journey as it paralleled my own in many ways. But just after her diagnosis surfaced in the media, Elizabeth Edwards disappeared from the radar -- perhaps like we all do in some way while immersed in the maze of cancer. So I lost track of her. But now -- almost two years later -- Edwards is back from cancer, back in the headlines, and back with a new book, Saving Grace.

Edwards, 57, reveals on the pages of her book the intricacies of her cancer ordeal. She shares that she experienced every side effect possible throughout her treatment. She bruised, bled, developed sores in her mouth, experienced numbness in her hands and feet, lost her hair, felt nauseated, ached in her bones and joints, and suffered yellowed and damaged nails -- and then chemotherapy stopped and she went on to the burning, blistering effects of radiation. Still, she managed to survive. And she thanks those who helped her survive -- for their tenderness, encouragement, humor, tears, and love -- and she writes all about it in her memoir that reveals how she juggled life and marriage and kids and cancer and how she arrived in a new place. A happy place.

Scientists have determined that mouth cancer develops in two different ways which dictates the seriousness of the disease. This finding, revealed on Tuesday, could lead to better prevention and treatment. In laboratory experiments with healthy, early, and advanced cancer cells, researchers were able to pinpoint differences in the cells that determined the aggressiveness of the cancer. They found faults in the p53 gene, which stops damaged cells from dividing, and in the p16 gene, which helps regulate and prevent cancer from developing. Both changes are linked to more aggressive tumors. This is first-time evidence that some mouth cancer tumors are more aggressive than others and are unfortunately linked to poor patient survival.

Oral cancer typically stems from pre-cancerous lesions, changes, or patches in the mouth -- all of which are early signs of cancer. Recognizing which pre-cancerous changes are more likely to develop into aggressive tumors would allow doctors an insight that could help them prescribe the best treatment.

Smoking, use of chewing tobacco, and heavy alcohol consumption are the leading causes of mouth cancer. And smoking and drinking are a very dangerous combination. Like lung cancer, mouth cancer usually develops in people age 50 or older.

When I received my treatments for breast cancer I was first given Adriamycin and Cytoxan. Following that I received Taxotere for 4 cycles every three weeks. That was in 2002. Things have changed somewhat now that Taxotere is sometimes given in dose dense quantities (every week for 12 weeks in some cases). I'm not sure if this regimen causes fewer side effects from the Taxotere. I have heard that it does.

I had a side effect called oral thrush resulting from Taxotere. When our immune systems are compromised we can develop oral thrush. I know others do suffer with thrush and are sometimes given a mouthwash to ease the discomfort. My oncologist prescribed Diflucan for 7 days straight after I would receive Taxotere treatments. This worked well to prevent and help with the mouth thrush. I would suggest asking your doctor about Diflucan if the mouthwash or other remedies do not work.

Another tip for Taxotere side effects is to get tissues with lotion in them. I had a terrible time with eye tearing. It is like when you get a sore nose from a cold. The tissues just made my eyes very red from rubbing them. The tissues with lotion in them helped tremendously with the irritation.

My last tip, although odd, would be not to drive when wearing fake eyelashes after a Taxotere treatment!! My eyes started to tear and the lash glue leaked into my eyes. I didn't crash or anything but I had to pull over because the glue formed a white film and I couldn't see! I'm glad a cop didn't pull over to see what was going on. I had black mascara running down my face and two fake eyelashes stuck where they weren't supposed to be. I do remember sitting in the car laughing about how ridiculous I looked.

Cancer treatment side effects (example: yeast infection in mouth!), CAN be ridiculous. Sharing tips among survivors however is smart.

Chemotherapy is a good remedy for killing cancer cells -- and I hope every day that it did its job and killed all cancer cells that may have floated away from my original breast cancer tumor. But one not-so-good side effect of this good remedy is the beating that healthy cells take in the process of this life-saving treatment. It will be a red-letter day when chemotherapy can target only cancer cells, while leaving healthy cells unaffected. And this day may be a bit closer for patients in Taiwan who find they are in the early stages of relapse with nasopharynx cancer.

On Wednesday, National Taiwan University Hospital introduced a new high-tech laser procedure -- potassium-titanyl-phosphate or KPT -- to vaporize cancer cells. Doctors use a small endoscopic camera and easily manipulate the laser to precisely eliminate the cancer cells in the back of the nose and the soft roof of the mouth -- without harming healthy cells. The procedure takes roughly 90 minutes and requires a two-day stay in the hospital. This procedure should only be used in the early stages of relapse, though, and first-time cancer patients should still seek chemotherapy. And while those in later stages of relapse can still receive the treatment, it will only relieve discomfort without solving the problem.

To date, there have been 16 successful KPT treatments for this disease that about 1,000 people in Taiwan contract each year.

On July 20 in Portland, Oregon, Pearl Jam held a benefit concert for the Northwest Chapter of the Crohn's and Colitis Foundation of America (CCFA) to raise awareness for a disease no one likes to discuss. Pearl Jam guitarist Mike McCready was diagnosed with Crohn's disease and ulcerative colitis twenty years ago and has gone public with what he personally felt for many years was an embarrassing disease.

McCready, a spokesperson for the NW Chapter of CCFA, said, "Having struggled with Crohn's disease for more than 20 years and experienced first hand difficulties in getting a diagnosis and treatment, I want to help others learn about the disease, how it is affecting them and how to find ways to cope."

UCB, a leading global biopharmaceutical company that recently launched Crohns and Me, an information and resource website for people with Crohn's disease, joined with CCFA, in sponsoring the Pearl Jam Portland benefit concert.