Women treated with Herceptin (trastuzumab) in combination with chemotherapy for early stage breast cancer showed that after five years the risk of congestive heart failure did not increase with time.

The findings of the National Surgical Adjuvant Breast and Bowel Project (NSABP) were presented at the 43rd annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago last week.

Heart damage occurs in around 5 percent of patients treated with Herceptin. It is the most significant side effect; women with existing heart conditions cannot take the drug. The study showed that women were either susceptible to heart problems or they weren't. The risk of long-term problems is the same as the risk that is there from the beginning.

The beloved member of our family, Spotted Calamity Jane, the oldest of our two Dalmatians had to be put down on February 17. It was the hardest decision I personally ever had to make, knowing when it was time to put her out of too much pain. The tears continue to flow and I know will for a long time. She had survived breast cancer at the age of 4 and continued to live a happy life loving her runs on the beach. 2 1/2 years ago she was diagnosed with renal failure, something that is irreversible but we continued to give her a low protein diet and top notch vet care and monitoring that included some acupuncture. It came to a point where we knew the pain was outweighing the good quality of life and the end was not far away and it was time to end the suffering. For 13 years she brought us joy and laughter and unconditional love. She was the leader and companion to our other 8 year old Dalmatian Kiva, who is deaf and followed Cally everywhere watching everything that she did. Watching the two of them running and playing on the beach in the water and sand are memories I will always carry. So we decided to have Cally cremated so we could spread her ashes out on the beach that she loved so much.

Then we were faced with another heart break. Seventeen days later we were told that her ashes had been lost and it floored us. It sent me curled up in a bed crying for a whole day. Family members and friends were outraged as our hearts once again tried to overcome the loss. We were told to get an attorney and sue for compensation. In quietness I walked through the trails in the woods near our house and thought what good could come from all of this. The vet of course refunded our money and offered to buy a memorial stone or something for us. I told him we would think about things. Then I decided that her life and the joy that she brought us should go to something positive and that I did not want to go through the stress and negativity of a law suit and staring at a meaningless stone memorial would not make it any better. That wouldn't change anything. So I suggested to the vet and the cremation services company, to donate money to my favorite charity, Indie Music For Life, that works with independent singer songwriters and comedians to raise money for cancer research and educational awareness programs on the benefits of music and laughter as therapy to cancer patients. This turned the tragedy into a positive. We have the great memories of her life with us and the knowledge that even in her death she has brought more good to the world. Cally is the beautiful dark colored Dalmatian on the left in this picture. Her spots continued to grow and grow which made her look like a black Dalmatian with white spots. We called her "our little negative" for those of you in the photography field that understand reverse imaging. She was a rare jewel and always a positive in our lives.

Aspirin and painkillers such as ibuprofen have been deemed too risky for use in the prevention of colon cancer, according to a federal task force.

The risk of intestinal bleeding, stroke, kidney failure, and other health problems led the US Preventative Services Task Force to conclude that taking more than 300 milligrams per day of drugs like Motrin, Advil, and Aleve is just too risky to outweigh the potential benefits of preventing cancer. And while taking less than 100 milligrams of such drugs can reduce the risk of heart disease, it does nothing to lower the rate of colon cancer.

Details about this task force study are published in Monday's issue of the Annals of Internal Medicine.

The first documented whole-ovary transplants are now on the map -- the United States map.

On February 5, a renowned infertility expert in St. Louis transplanted a whole ovary from one woman into her sister in order to enable the sibling to have children after a battle with ovarian cancer that resulted in early and permanent menopause.

Dr. Sherman Silber, who performed the same type of transplant on twins last month and has previously restored fertility via ovary tissue transplants, believes his success is unmatched. Apparently, surgeons in China have reported similar success but offer few details to support their claim. And due to a lack of published material about the case, it is believed Dr. Silber's ovary transplants may be the world's first scientifically documented cases.

Silber says whole-ovary transplants, that could potentially allow women with cancer to freeze an ovary, undergo treatment, and then have the ovary returned to restore fertility, could also one day help women who don't have cancer but experience natural premature ovarian failure, which leads to early menopause.

While both of Silber's ovary transplant patients are awaiting news about their status of their fertility, Silber awaits the long-term results of his work. Ovarian tissue transplants last a few years, but whole ovary transplants should last for decades, he says.

Three days ago, author and New Yorker staff writer Calvin Trillin's new book About Alice was released. He gives the reader a portrait of his life with his wife Alice in what is called, "a straightforward honest portrait of their marriage and family life in this slim volume, opening with the suggestion that he had previously mischaracterized Alice when he wrote her into stories that were essentially sitcoms."

Alice, a non-smoker who was diagnosed with lung cancer in the 1970s, passed away the day after 9/11 on September 12, 2001 of heart failure that resulted from complications of radiation cancer treatment. During her life, her creativity, intelligence, talent and non-conformity led to her becoming an accomplished writer, editor and educator. As a cancer survivor, Alice wrote the article Of Dragons and Garden Peas: A Cancer Patient Talks to Doctors about her experience as a cancer patient in the Land of the Sick.

Trillin wrote of meeting his wife, "My first impression was that she looked more alive than anyone I'd ever seen. She seemed to glow." About Alice is a loving tribute of a fascinating woman.

For 18 months, New Zealand resident Heather Kubiak lived with undiagnosed breast cancer. It was no fault of her own that her disease was left undetected for all this time. It was the fault of the hospital staff who lost her file -- marked urgent -- and thus failed to communicate with her about the cancer living in her body.

In December 2003, Kubiak had both breasts removed because her cancer had spread. And so began the battle for her life -- and the battle against a system that admittedly botched up her medical care due to organizational failure.

It took years to resolve her claim but earlier this year, Kubiak, a wife and mother of four, received a lump-sum compensation of -- $9,000. That's $16.66 per day for every day of the 18 months her undiagnosed breast cancer continued to spread.

It was important for Kubiak to see her hospital held accountable -- and while $9,000 hardly makes up for what she has lost -- she is happy the legal ordeal is over. And she hopes her experience will motivate others to actively pursue their own medical misadventures.

"I do worry for people who aren't articulate enough or strong enough to fight the system because you have to keep on and on," she says.

Smoking is not an easy habit to break, and of the many methods tried, only a handful seem to work. Of the methods that do seem to work -- nicotine-replacement products; bupropion drugs; counseling; classes; calling a helpline or talking to a health professional -- younger smokers between the ages of 16 and 24 years who smoke and try to quit only use one of the recommended methods of help by talking to a professional. Because of this, younger smokers are less likely to be successful in quitting, according to the US Centers for Disease Control and Prevention (CDC).

During the 2003 National Youth Smoking Cessation Survey, the CDC found that younger smokers most often tried to quit smoking by cutting back on the number of cigarettes they smoked each day; not buying cigarettes; exercising; using the buddy system and trying to quit with a friend; telling others they were quitting and changing to a lighter brand of cigarette, switching to chewing tobacco, snuff, or other tobacco products. None of these methods are recommended by the US Public Health Service.

According to the National Youth Smoking Cessation Survey, 77 percent of younger smokers have tried to quit at least once without success. Over a third have tried to quit smoking numerous times without success. Researchers suggest that many younger smokers may need help with other high-risk behaviors such as binge drinking; depression or ADD/ADHD.

If you are a younger smoker who is trying to quit, the CDC encourages you to call 1-800-QUIT-NOW or talk to your physician about methods that might lead to more success. The 2-page summary of the National Youth Smoking Cessation Survey is available as a pdf document.

Anthracyclines are a type of chemotherapy that treat several different types of cancer including (but not limited to) leukemia, lymphomas, breast, uterine, ovarian, and lung cancers. Anthracyclines are technically antibiotics, although their high toxicity precludes their use as such. A major side effect from this type of chemotherapy is that it can lead to heart problems in some patients. The risk for heart problems can remain elevated long after cancer treatment is finished.

Researchers are looking to find ways to lower the risk of patients developing heart problems after treatment without sacrificing the effectiveness of the drugs. They reviewed information from six previously published clinical trials and found that if the infusion of anthracyclines are given slower, over a period of six hour or longer, it appears to reduce the risk of heart problems.

Available anthracyclines include:

• Daunorubicin
• Doxorubicin
• Epirubicin
• Idarubicin
• Mitoxantrone

At one time, patients with blood cancers were treated with harsh drugs, like interferon or hydroxyurea, yet only two to three percent would ever achieve any sort of remission. Many would suffer such extreme side effects from these drugs they would stop taking the medication early, decreasing even further their potential odds for survival.

The fate of these patients is changing. And the proof is in print -- in today's issue of the New England Journal of Medicine.

It all began with the study of a highly targeted molecular therapy called STI571 -- designed to block the genetic aberration that gives rise to chronic myeloid leukemia (CML), a disease that affects about 6,000 Americans every year. A clinical trial followed, and a compound marketed by the drug company Novartis emerged. Today, this compound is know as Gleevec.

In the clinical trial of Gleevec, 1,106 CML patients were randomly chosen to receive either Gleevec or Interferon. Early results were so encouraging that all but three percent of the participants using Interferon switched to Gleevec. Five-year survival rates were 89 percent. And 93 percent of patients saw no progression to the acute phase of the disease. Many patients witnessed their blood counts return to normal, and a large number experienced a reverse in the gene mutation that causes CML. Virtually no one reported side effects while using the drug.

Despite a rare reaction that can cause heart failure, Gleevec has now been approved by the FDA for the treatment of six other rare, life-threatening disorders. And other drugs similar in nature to Gleevec are hitting the scene. Some believe long-term suppression of CML will come from a cocktail of these types of drugs.

For now, Gleevec -- on its own -- is a success story.

The overall cure rate for the 20,000 children diagnosed with cancer in the United States each year is more than 75 percent. Sounds good -- especially when 50 years ago, most children diagnosed with cancer died. But considering that only one in three childhood cancer survivors remain healthy, perhaps this is not such good news.

Thirty years after diagnosis, about 40 percent of survivors have a serious health problem and one-third have multiple problems. Strokes, heart disease, and kidney failure are just a few of the major health concerns that plague many survivors who have entered adulthood.

Doctors have long known that cancer treatments can cause new cancers later in life. But the Childhood Cancer Survivor Study -- the largest ever childhood study of its kind -- shows there are other long-term health problems. Researchers studied 10,000 survivors -- past studies examined 200-300 survivors -- and found these survivors were eight times as likely as their siblings to develop severe and life-threatening conditions. They found survivors of bone tumors, nerve and brain cancer, and Hodgkin's disease faced the highest risk.

The source of these later-in-life health problems vary. Kidney failure may result from damage caused by chemotherapy or radiation or the infections children suffer when their immune systems are weakened. Drugs used to treat infections may also be to blame. Strokes may result from head and chest radiation.

Cancer treatment for people of all ages comes with a price. We buy time, we buy life in exchange for the unknown. But for children -- who stand to live longer than adults -- there is a greater unknown. Sadly, there is a dark side to surviving cancer.

ABC World News Tonight partnered with the Centers for Disease Control and Prevention, the National Cancer Institute and the North American Quitline Consortium to present a special series Quit to Live. According to statistics, approximately 440,000 Americans will die from smoking-related illnesses this year. A more encouraging statistic is while there are 46 million smokers, for the first time, there are more ex-smokers than smokers.

The Quit to Live series is a comprehensive resource for the 70 percent of smokers who have indicated they are interested in quitting. At Quit to Live, you can watch the complete special series coverage in video broadcast reports; watch broadcast plus exclusive web-only content; view the videoblogs of Tracy, Jose, Meg and Alyce; how to quit thinking about quitting and compare different methods and find groups that can help.

You can read ABC medical editor Dr. Tim Johnson and experts from the nation's leading cancer centers answers to questions about smoking at Ask Tim. In addition to original reports and reviewed resources, they offer community to connect with others. This week, ABC News revisited the Quit to Live special series on the anniversary of Peter Jennings death to lung cancer. Any smoker interested in quitting will find this special series of great value -- you might want to start by watching the video Expert Interview on How to Quit.

Welcome back from the weekend! Here is a review of what we were talking about during the second week in July in our other health blogs.

From The Cardio Blog:

• Bucindolol: experimental heart failure drug.
• Mammograms can find heart health problems.
• Eggs: bad or not bad for heart health -- which is it?
• The clock of life and time of day determines heart health.
• Extreme obesity raises mortality rate in women.
• Austrailian stem cell research innovates new heart treatment.
• Public physical activity program helps weight loss, lower blood pressure.
• Tuna imported from Latin America has highest mercury level.
• Eating less helps slow aging process.
• Teens helped to learn healthy diet habits with household food rules.
• Volunteer work helps seniors stay active and healthy.
• Working overtime worse for womens health.
• Aging and single living combined linked to higher heart disease risk.
• Tubby kids motivated to exercise by reward of TV time.
• Humidity and high temps linked to rise in summer heart attacks.
• Comedian Red Button dies of vascular disease.
• Migraine aura linked to increased heart attack stroke risk.
  

From The Diabetes Blog:

• Martial arts black belt uses youth group to fight diabetes.
• FDA approves GlaxoSmithKline diabetes drug.
• Pink Floyd Syd Barrett dies from diabetes complications.
• Update on fatal NC car crash involving diabetic driver.
• Major study links Type 2 diabetes and glaucoma risk.
• Life insurance industry plays catch-up.
• A1c Champions program trains diabetes mentors.
• Danish study confirms suspected diabetes, multiple sclerosis link.
• Debate continues on virtues, shortcomings of inhalable insulin, Exubera.
• Blogger's advice to T2 diabetics: follow in footsteps of movie producer Weinstein.
• Diabetes, obesity blamed for sky-high US kidney failure rates.
• Canadians await approval of inhalable insulin.
• Lifestyle ed could greatly reduce diabetes onset in older Americans, say researchers.

To your good health! To a great week!

Gleevec is proving over time to be such a promising breakthrough in successfully treating leukemia patients that even with the discovery that it can cause congestive heart failure researchers are still telling cancer patients not to stop taking the drug.

Dr. Thomas Force, of Jefferson Medical College in Philadelphia, the study's author, said that this is not a case of Vioxx and while ten patients taking Gleevec for chronic myelogenous leukemia developed severe congestive heart failure, the take away message of the study is that doctors need to be aware that cancer drugs like Gleevec can have severe effects on the heart and the heart health of patients taking Gleevec needs to be closely monitored.

If you plan to use the nicotine patch to quit smoking, it would be nice to know up front if it's going to work. Because nothing is more discouraging than making an attempt at something and believing you have help -- only to find out the help was no help at all. The problem seems to be in the basic fact that nicotine metabolizes in the body at different rates for different people. The higher the metabolism rate, the more cravings a smoker experiences. The more cravings, the less likely a standard nicotine patch will be effective. Researchers believe that a simple blood test to measure the rate at which a smoker metabolizes nicotine can predict the success or failure outcome of a smoking cessation program using the patch.

"If a prospective study replicates these results, we will be in a position to recommend this blood test to tailor the type and dose of nicotine replacement therapy for smokers who wish to quit," states Caryn Lerman, PhD, Associate Director for Cancer Control at the Abramson Cancer Center and Director of the University of Pennsylvania Transdisciplinary Tobacco Use Research Center.

Here's what I am thinking -- if they know how the body metabolizes nicotine to satisfy the addictive cravings for nicotine, why can't they come up with something that blocks the process before it begins? Thereby making smoking a completely unsatisfactory experience. Just a thought.

"The reports of my death have been greatly exaggerated." -- Mark Twain

According to several international news services and tabloid newspapers with an online presence, Elizabeth Taylor, legendary movie star and cancer survivor, is suffering heart failure and near death. Reported to be bedridden at her home in Bel Air, California, she is said to have cancelled her annual Easter party to plan her funeral. According to an unnamed friend, "Liz is inching closer to death every day and she knows it. It is not a pretty picture. She's not leaving a lot of money to her children. She wants the bulk of her fortune to go to AIDS research." I guess dying isn't enough of a news story, a publisher decided to add this scurrilous gossipy little comment from an anonymous friend on how her estate will be settled. Other than her attorneys and estate planners, I doubt few know the status of her will.

Her publicist, Dick Guttman, states that Taylor is not near death, and is instead, quite busy with her successful perfume and jewelry lines and the work she does for AIDS. "The endless health stories surrounding Taylor's supposed impending death," Guttman says, "have just become exasperating." Mark Twain predicted this one right. I cannot find any credible reports indicating that Guttman is playing smoke and mirrors with the public. All the reports of Taylor's impending death do seem to be coming from very specific, and perhaps slightly questionable, sources for news information. My vote for accuracy goes to Guttman. We send her our best wishes for continued good health.